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Not all routers in an AS need to participate in route reflection The key aspect is that the reflectors need to be fully meshed with the reflectors of other clusters and with any other iBGP speakers that are not part of a cluster (Figure 116) With respect to route reflectors, those iBGP speakers are called conventional BGP speakers Like all powerful features, route reflectors provide powerful ways to get your network in trouble One of the most common problems is when a provider uses them in a POP and does not carefully set BGP preferences and imported IGP metrics such that an intra-POP route is always preferred to an inter-POP route This is done for the same kind of loop prevention reasons that intra-area routes are always preferred in ISIS and OSPF There is no protocol-level reason why a router that is a reflector in one cluster can t be a client in a higher level cluster By building a hierarchy of clusters, there is no need ever to have a huge number of iBGP peers (see Figure 117) Again, this can get you in trouble, if, for example, a lower-level client is pointed to a higher-level reflector You also must make sure that each cluster has a unique cluster ID Remember how BGP prevents loops by rejecting incoming AS paths that contain the local autonomous system s AS number The same principle is used in clusters: If an incoming route contains the equivalent of the cluster ID in a path, it is assumed to be a loop To avoid loops, manipulate

Melatonin is a methoxyindole generated by enzymatic conversion of serotonin It is synthesized and secreted principally by the pineal gland Light is able to suppress or synchronize melatonin production This explains the diurnal rhythm of melatonin secretion with a maximum during night time hours (02:00 04:00 h) [320,321] Melatonin receptors are present in different organs and involved in multiple physiologic functions [322] The primary function of

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your IGP metrics so that intra-POP IGP metrics are preferred to inter-POP IGP metrics The reason ISPs generally prefer not to receive MEDs from customers closely relates to this issue of potential loops, because the MED value exported from the customer could be totally incompatible with that used by the provider For example, what if the customer used RIP as an IGP metric and exported the hop count as the MED

18 with reduced functional potency of melatonin receptors [322] Decreased melatonin concentrations were found in some, but not all, patients suffering from Alzheimer disease [325] In vitro studies suggest that the antioxidative effects of melatonin may reduce the neurotoxicity of the amyloid beta, and open trials reported a bene cial effect of melatonin on sleep and progression of cognitive impairment in Alzheimer patients [325] However a multicenter placebo-controlled trial failed to prove that melatonin has a clinically signi cant effect on objective measures of sleep in patients suffering from Alzheimer disease [327] The preceding meta-analysis implies that exogenous melatonin may have some use in treating insomnia, particularly that associated with nocturnal melatonin de ciency in aged individuals [325] or with an abnormal pattern of melatonin secretion: blind people, jetlag (con rmed by a meta-analysis) [328], with an overall 50% reduction in subjective assessment of symptoms using 5 mg fast-release melatonin and speci c instructions for timing of the treatment [321], shiftwork, delayed sleep phase syndrome, and the elderly [321] Physiologically relevant doses of 05 5 mg orally and administration at bedtime are generally recommended [322] However the optimal dose and time of administration need further delineation In addition, although melatonin treatment seems to be safe because of its very low toxicity and absence of any signi cant side effects [325], no data on long-term follow-up is available No effect on sexual function or dysfunction has been reported Presently, available data do not allow us to conclude that melatonin may have a role in extending normal longevity, or is a rejuvenating agent However some of its actions may be bene cial for the aging process, especially its sleep-promoting effects More extensive studies are needed to con rm whether it may improve the quality of life in old age Presently there is no recommendation for routine melatonin replacement in the elderly.