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Hormones, Metabolism, Aging, and Men s Health [270,273,274] The ability for the conversion of active hormones in the peripheral tissues, where the hormone will be active, is called intracrinology This phenomenon has been outlined for sex steroids very well by the work of Labrie [275,276] Different peripheral tissues are able to selectively make androgens or estrogens This is possible because of numerous different 17 -hydroxysteroid dehydrogenase enzymes that are able to selectively control the correct intracellular concentration of the correct sex steroid [277]

11 Table 112 Bandwidth and Media versus Pipes and Hoses (No Single Point of Failure) IMPLEMENTATION (NO SINGLE POINT OF FAILURE) Minimum 2 OC-48s (at 25 Gbps) No single point of failure 4 OC-48s* or 2 OC-192s

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The sex steroid activity of DHEA requires it to penetrate the cell and become converted to the active downstream sex steroids Recently, a putative receptor speci c for DHEA has been identi ed on endothelial cell plasma membranes with which structurally related steroids failed to compete for binding [278] These receptors are coupled to eNOS activity through G proteins, and it has been shown that physiologic concentrations of DHEA acutely increase NO release from intact vascular endothelial cells, by a plasma membrane-initiated mechanism [279] These effects on the vascular wall may be both genomic and non-genomic, and both effects are independent of other steroid hormone receptors [280] These ndings have possible implications for DHEA as an anti-atherogenic compound, as DHEA may inhibit human vascular smooth muscle cell proliferation independent of androgen or estrogen receptor activity [281] DHEA has also been shown to increase endothelial proliferation and improve endothelial function in vitro using endothelial cells, as well as in vivo measured by ow-mediated dilatation of the brachial artery, by a mechanism independent of either androgen or estrogen receptor activity [281] Iwasaki et al demonstrated that DHEA and DHEA-S both had possible anti-in ammatory and immunomodulatory effects by inhibiting proin ammatory cytokineinduced transcription, an effect that neither estradiol nor T could duplicate [282]

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Sometimes it can pay to enter into an arrangement with a partner that allows you to reap a return from the development of your land Perhaps you supply the land alone, or commit to arranging the servicing; perhaps you do more, such as undertake rezoning that poises it for development Whatever the arrangement, this can allow you to see a better return than you would by selling off the raw land to an eager developer A partnership could also speed the sale of the land if your hopes for the area where you bought haven t quite come true One developer we know had a tract of land subdivided for sale as development lots for single-family homes But the lots weren t selling So the developer approached a home builder who designed custom homes on the lots The partnership added value to the land, allowing the developer to sell the lots for much more than the market value of the bare land, and the home builder was able to make a few sales, too

* You ll need four OC-48s because, while a single OC-48 can handle half the aggregate, no single OC-48 can handle the bandwidth of customer 3 and any other customer, assuming that no load sharing splits the customer 3 workload

DHEA de ciency can be seen in several disease states Regardless of the etiology, patients with pri-

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